Search results for "Double knockout"

showing 2 items of 2 documents

Generation of C5aR1/C5aR2 Double Knockout Mice by CRISPR/Cas9 for Revealing Novel Aspects of Lung Injury

2019

CRISPRBiologyLung injuryDouble knockoutCell biologyD32. ACUTE LUNG INJURY AND ARDS: CLINICAL AND MECHANISTIC STUDIES
researchProduct

Increased susceptibility of complement factor B/C2 double knockout mice and mannan-binding lectin knockout mice to systemic infection with Candida al…

2008

Candida albicans is the major cause of systemic fungal infections in immunocompromised patients. We investigated the susceptibility of mice deficient in complement factor B and C2 (Bf/C2-/-), C1q (C1qa-/-), and mannan-binding lectin (MBL)-A (MBL-A) and MBL-C (MBL-A/C-/-) to systemic infection with C. albicans. Animals were infected i.p. with 10(8)C. albicans blastoconidia and monitored for mortality. Bf/C2-/- mice showed high mortality (over 90%) within the study period of 3 weeks. In contrast, mortality in C1qa-/- mice was below 15% whereas that of MBL-A/C-/- mice was 40% (P0.001). Intravenous infection of mice with 8x10(5) blastoconidia resulted in the same trend with Bf/C2-/- mice being …

Immunologychemical and pharmacologic phenomenaOpportunistic InfectionsMannose-Binding LectinBlastoconidiumComplement factor BMicrobiologyMicePhagocytosisSpecies SpecificityCandida albicansAnimalsGenetic Predisposition to DiseaseCandida albicansDouble knockoutComplement ActivationMolecular BiologyMannan-binding lectinMice KnockoutbiologyCandidiasisLectinComplement Pathway Mannose-Binding LectinComplement C2bacterial infections and mycosesbiology.organism_classificationCorpus albicansKnockout mousebiology.proteinComplement Factor BMolecular Immunology
researchProduct